What Is D-Limonene?
D-Limonene, also known as limonene or delta-limonene, is the terpene that is well known for giving citrus fruit its aroma. If you like drinking orange juice in the morning, you have already experienced the benefits of limonene. It is believed to have mood uplifting and energizing properties that can help with depression and fatigue. Limonene is used commercially in products for its fragrance and its anti-microbial and insecticidal properties. In cannabis, limonene can be found in some strains that smell like lemons, but not always. The combination of terpenes contributes to the smell, and some terpene combinations can have a citrus like aroma even if limonene isn’t detected. High concentrations of limonene are common in strains that have uplifting, stimulating, and energizing effects.
Where is D-Limonene Found?
Limonene is found in large concentrations in citrus fruits like lemons, limes, and oranges. You can also find it in celery, mint, fennel, thyme, and many other plants. Many products that are lemon scented use limonene for the fragrance. Limonene is found in cleaning products, deodorant, shampoo, air fresheners, and even in flea and tick repellant for pets. Additionally, it is used as a flavoring agent for food and beverages.
Potential Therapeutic Benefits
Cultivars with D-Limonene
- Alipanah, H., Farjam, M., Zarenezhad, E., Roozitalab, G., & Osanloo, M. (2021). Chitosan nanoparticles containing limonene and limonene-rich essential oils: potential phytotherapy agents for the treatment of melanoma and breast cancers. BMC complementary medicine and therapies, 21(1), 186. https://doi.org/10.1186/s12906-021-03362-7
- Araújo-Filho, H. G., Dos Santos, J. F., Carvalho, M., Picot, L., Fruitier-Arnaudin, I., Groult, H., Quintans-Júnior, L. J., & Quintans, J. (2021). Anticancer activity of limonene: A systematic review of target signaling pathways. Phytotherapy research : PTR, 35 (9), 4957–4970. https://doi.org/10.1002/ptr.7125
- Britannica, T. Editors of Encyclopaedia (2021, March 19). lemon. Encyclopedia Britannica. https://www.britannica.com/plant/ lemon
- Chaudhary, S. C., Siddiqui, M. S., Athar, M., & Alam, M. S. (2012). D-Limonene modulates inflammation, oxidative stress and Ras- ERK pathway to inhibit murine skin tumorigenesis. Human & experimental toxicology, 31(8), 798–811. https:// doi.org/10.1177/0960327111434948
- D-limonene. CPID. (n.d.). Retrieved March 22, 2022, from https://www.whatsinproducts.com/chemicals/view/1/206/005989-27-5/ d-Limonene
- Komiya, M., Takeuchi, T., & Harada, E. (2006). Lemon oil vapor causes an anti-stress effect via modulating the 5-HT and DA activities in mice. Behavioural brain research, 172(2), 240–249. https://doi.org/10.1016/j.bbr.2006.05.006
- Komori, T., Fujiwara, R., Tanida, M., Nomura, J., & Yokoyama, M. M. (1995). Effects of citrus fragrance on immune function and depressive states. Neuroimmunomodulation, 2(3), 174–180. https://doi.org/10.1159/000096889
- National Center for Biotechnology Information (2022). PubChem Compound Summary for CID 22311, Limonene. Retrieved March 22, 2022 from https://pubchem.ncbi.nlm.nih.gov/compound/Limonene.
- O’Bryan, C. A., Crandall, P. G., Chalova, V. I., & Ricke, S. C. (2008). Orange essential oils antimicrobial activities against Salmonella spp. Journal of food science, 73(6), M264–M267. https://doi.org/10.1111/j.1750-3841.2008.00790.x
- Pultrini, A., Galindo, L. A., & Costa, M. (2006). Effects of the essential oil from Citrus aurantium L. in experimental anxiety models in mice. Life sciences, 78(15), 1720–1725. https://doi.org/10.1016/j.lfs.2005.08.004
- Richter, G., Hazzah, T., Hartsel, J. A., Eades, J., Hickory, B., & Makriyannis, A. (2021). Chapter 38 – Cannabis sativa: an overview. In R. C. Gupta, R. Lall, & A. Srivastava (Eds.), Nutraceuticals (2nd ed., pp. 603-624). Academic Press. https://doi.org/10.1016/ B978-0-12-821038-3.00038-0
- Vigushin, D. M., Poon, G. K., Boddy, A., English, J., Halbert, G. W., Pagonis, C., Jarman, M., & Coombes, R. C. (1998). Phase I and pharmacokinetic study of D-limonene in patients with advanced cancer. Cancer Research Campaign Phase I/II Clinical Trials Committee. Cancer chemotherapy and pharmacology, 42(2), 111–117. https://doi.org/10.1007/s002800050793
- Yu, X., Lin, H., Wang, Y., Lv, W., Zhang, S., Qian, Y., Deng, X., Feng, N., Yu, H., & Qian, B. (2018). d-limonene exhibits antitumor activity by inducing autophagy and apoptosis in lung cancer. OncoTargets and therapy, 11, 1833–1847. https:// doi.org/10.2147/OTT.S155716
- Zhang, L. L., Yang, Z. Y., Fan, G., Ren, J. N., Yin, K. J., & Pan, S. Y. (2019). Antidepressant-like Effect of Citrus sinensis (L.) Osbeck Esse ntial Oil and Its Main Component Limonene on Mice. Journal of agricultural and food chemistry, 67(50), 13817–13828. https://doi.org/10.1021/acs.jafc.9b00650